Department of Microbiology, Federal University Oye-Ekiti, Ekiti State, Nigeria
*Corresponding author e-mail: stephen.ojo@fuoye.edu.ng
Online published on 23 January, 2020.
The aim of study was to evaluate the wound healing activity of Diodia scandens and Phyllanthus amarus and their synergistic effect against wound infection. Fresh whole plant's extract of P. amarus and D. scandens were processed using soxhlet ethanol extraction technique. Excision/wound was inflicted on swiss albino rats kept at controlled temperature. Extracts were applied and the wound healing potentials were evaluated at interval of 3 days for 18 days. Statistical analysis was performed. The synergistic application of D. scandens and P. amarus showed the highest wound contraction in comparison with D. scandens and P. amarus used separately. The healing rate of the different part of the body of the animals differs with the head, having a higher percentage of wound contraction from 3 to 9 days (71.2% to 73.6% for D. scandens-treated group of rats and 64.0% to 66.0% for synergistic-treated groups) in comparison with the back (46.0% to 49.0% for D. scandens-treated group of rats and 64.0% to 66.0% for synergistic-treated groups). Results obtained from this study suggested the beneficial and significant effects of plant extract for the acceleration of wound healing contraction in rats.
Diodia scandens, Phyllanthus amarus, synergistic, excision wound model, albino rats, bacteria
