1Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok65000, Thailand
2Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand
*Corresponding author e-mail: suratb@nu.ac.th
Online Published on 16 August, 2022.
The seven major phytochemicals, farnesol (1), 5,6-dehydrokawain (2), pinocembrin (3), cardamomin (4), naringenin (5), pinocembrin chalcone (6) and alpinetin (7) were isolated from seed extract of Alpinia mutica. The structures were characterized using NMR spectroscopic data and HRESIMS. These isolated compounds were tested for their inhibition of α-glucosidase activity. Compound 5 was found with most potent inhibitory activity with IC50 value of 8.77 ± 1.04 μM and compound 3 also showed high activity with IC50 value of 62.77 ± 2.18 μM. Furthermore, the study on their biosynthetic origin of isolated compounds revealed that styrylpyrone and flavonoids from A. mutica seed originate from cinnamoyl CoA or p-coumaroyl-CoA with malonyl-CoA chain extension. Moreover, compound 6 was the precursor for flavonoids formation of A. mutica seed and this is the first report on the isolation of importance precursor, 6 from A. mutica.
Alpinia, Alpinia mutica, Seed, Styrylpyrone, Flavonoids, α-glucosidase
