1Department of Biotechnology, DG Vaishnav College, Arumbakkam, Chennai-600106, Tamil Nadu, India
2Department of Biotechnology, Vel Tech High Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Avadi, Chennai-600062, Tamil Nadu, India
*Corresponding author e-mail: pavithram@dgvaishnavcollege.edu.in
Online Published on 30 November, 2022.
Seeds from various plants are known to have many phytochemicals that are capable of defending them from oxidative damage and protect them from possible pathogens like yeast, fungi, virus and bacteria. Through this work we aim to study the antimicrobial activity of Annona squamosa, Mangifera indica and Syzygium cumini seed extracts of four different solvents like hexane, chloroform, methanol and ethanol. About twenty five microbial samples were isolated from different sources and used against these solvents and the antimicrobial activities of the seed extracts were studied. Standard biochemical tests were carried out for the characterization of gram-negative bacteria. Molecular interaction analysis for the 13 compounds of seed extracts against the 3 protein antigens of food-borne diseases causing organisms (protein-ligand docking) were carried out using bioinformatics tools. The chloroform seed extracts showed potential anti-microbial activity and thus can be used as a natural therapeutic substituent against food borne diseases and to prevent concerns over drug resistance caused by antimicrobial agents.
Molecular interaction analysis, Antimicrobial activity, Biochemical tests, Food borne diseases
