1Department of Botany, A.V.V.M. Sri Pushpam College (Autonomous), Poondi (Affiliated to Bharathidasan University), Thanjavur-613503, Tamil Nadu, India
2Department of Botany, Scott Christian College (Autonomous), Nagercoil-629003, Tamil Nadu, India
*Corresponding author e-mail: sathiageetha@gmail.com
Online Published on 31 March, 2023.
Aristolochia tagala is a medicinal herb used widely to treat snakebite, stomachache, and poison bites in ethnobotanical literature. Due to the little data available in the literature about the plant, this study was planned to ascertain its free radical scavenging potential activity using eight in vitro antioxidant assays with six solvents. Hydroalcoholic extract of A. tagala leaf showed strong antioxidant effect in the DPPH (IC50 of 30.80±0.337 ug/mL), hydroxyl radical (48.11±0.432 ug/mL), superoxide (46.64 ug/mL), metal chelating (68.50 mg EDTA/g) and phosphomolybdenum (27.00±0.56 AAEmg/g) assays. Methanolic (IC50 of 044.89 mg/mL), petroleum ether (IC50 of 115.81±0.598 ug/mL) and aqueous (135.50±0.5 mM Fe (II)/ mg) extracts of A. tagala leaf showed maximum antioxidant effect in ABTS, nitric oxide and FRAP assays, respectively. Based on the results A. tagala leaf found to possess strong antioxidant potential and can be explored further for different pharmaceutical applications in the development of therapeutic drugs.
Indian birthworth, Aristolochiaceae, Extraction, Free radicals, Pharmaceuticals
