Medicinal Plants - International Journal of Phytomedicines and Related Industries

Diabetes Mellitus (DM) is a hormonal disorder characterized by decreased insulin levels in the blood. The use of synthetic drugs for DM treatment is associated with various adverse effects that can harm patients, leading to an increased demand for herbal remedies. Clitoria ternatea flower extract (CTE) is believed to be antidiabetic because of its antioxidant activity. This study was conducted to determine the potential of CTE as an antidiabetic in rats that have been induced by streptozotocin (STZ) and a high-fat diet (HFD). In vivo testing was conducted on Sprague Dawley rats induced by STZ and HFD, administering CTE at doses of 200, 400, and 800 mg/kg BW orally for 28 days. The expression of pancreas protein αamylase using immuno-histochemistry (IHC) and pancreatic glucagon was assessed using the qRT-PCR method. Results indicated that CTE was able to restore the pancreas state close to normal, decrease the expression of the α-amylase protein, and reduce glucagon gene expression in the DM rats model. The concentration of 800 mg/kg BW of CTE exhibited the highest efficacy. This study showed that CTE holds promise as a treatment for diabetes mellitus.