Biomedical applications of Elaeocarpus ganitrus (Rudraksha) bead extract mediated silver nanoparticles

The present study investigated the antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative potential of Elaeocarpus ganitrus (Rudraksha) bead extract mediated silver nanoparticles (REMAG). The antioxidant activity of biogenic silver nanoparticle (AgNPs) was measured by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2'-azino-bis3-ethylbenzthiazoline-6-sulfonic acid (ABTS) free radical scavenging activities while anti-inflammatory, anti-diabetic, anti-neurodegenerative properties was evaluated through anti-proteinase activity, alpha amylase enzyme inhibition, and acetylcholinesterase enzyme inhibition activities, respectively. The study outcomes demonstrated a comparable dose-dependent response of REMAG with that of reference standards for the tested biomedical properties. The IC₅₀ values for DPPH and ABTS free radical scavenging of REMAG were 29.35 µg/ml and 12.09 µg/ml respectively. The IC₅₀ values for anti-inflammatory, anti-diabetic, and anti-neurodegenerative activities of REMAG were 8.92 µg/ml, 24.60 µg/ml and 17.4 µg/ml respectively. Further, in vivo safety and efficacy assessments are warranted to confirm their in vitro biomedical applications.