The impact of five millet varieties on cancer treatment: An overview of scientific findings from in-vitro and in-vivo preclinical studies
Abstract
The Siddha system is an ancient medical tradition focused on promoting health and treating illnesses. Its primary goal is to maintain well-being through the consumption of nutritious and wholesome foods. Millets have been extensively mentioned in Siddha classical texts for their therapeutic properties. This study examines 5 millets, (finger millet, pearl millet, proso millet, foxtail millet, and barynard millet) anti-cancer properties in 18 in-vitro and 6 in-vivo models, based on 20 articles from reputable databases like Web of Science, Google Scholar, Scopus, and Pubmed. The findings demonstrated notable anti-cancer effects on colon cancer cell lines, breast cancer, liver cancer, human melanoma cells, and chronic myeloid leukemia, along with anti-proliferative activity. Additionally, it outlines the crucial mechanisms and signaling molecules involved in cancer prevention. This study seeks to address the research gap in the application of millets and motivate further clinical trials of millet-based anticancer agents for both humans and animals.
Keywords
Anti-cancer, Anti-carcinogenic, Cancer, Millets, Pre-clinical trial, Traditional food
