Abelmoschus escluentes (L.) treatment attenuates the streptozotocin- nicotinamide induced diabetes mellitus type II in rats: A scientific validation

Diabetes mellitus is a clinical disorder characterized by excessively increased blood glucose levels produced because of insulin deficiency. Although a lot of therapeutics agents are being utilized for its treatment, even then there is need for discovery of new agents. The adverse effects of synthetic medicine are challenges to combat alongwith complications, arise due to progression of diabetes mellitus. Treatment of various disorders using herbal medicine has experienced exponential growth in recent years, and these treatments are gaining interest in both developed and developing countries because of their natural origins and minimal adverse effects. Therefore, present study was aimed on in-vitro and in-vivo efficacy of ethanol and aqueous extracts of Abelmoschus esculentus leaves for its antioxidant, anti-hyperlipidemic and anti-diabetic activity against streptozotocin-nicotinamide (STZ-NA) induced type-II diabetes mellitus in rats. Diabetes mellitus type II was induced by administration of streptozotocin-nicotinamide. After induction of diabetes, the rats with blood glucose level more than 200 mg/dl were selected and administered with ethanol and aqueous extract of A. esculentus leaves orally at a dose of 200 mg/kg for 28 days. A significant decrease in blood glucose level, total cholesterol, low-density lipoprotein (LDL), triglycerides (TG), and upsurge in high-density lipoprotein (HDL) were observed after 28 days treatment. The extracts also exhibited a significant decrease in MDA level and increase in GSH, CAT and SOD level. The extracts of this plant were found beneficial in the treatment of diabetes mellitus type II and associated dyslipidemia.