Bioactive metabolites from Catharanthus species: Advancing antimicrobial drug discovery

Madagascar periwinkle is recognized for having a wide range of pharmacological characteristics as well as bioactive substances, including glycosides, alkaloids, and flavonoids. Catharanthus roseus, has proven to be exceptionally important in the field of medicine in many countries. For the past few decades, C. roseus has been utilised worldwide to cure a variety of illnesses, such as cancers and diabetes. The entire plant, including the bark, roots, stems, and flowers, is a rich source of many bioactive substances. MDR (Multi Drug Resistant) bacterial strains’ cell walls and cytosolic target proteins were used for molecular docking after the structure of possible phytocompounds from plants was obtained from the (Indian Medicinal Plants, Phytochemistry and Therapeutics) IMPAT database. Molecular docking experiments revealed that the proposed compounds (vinblastine, vincristine, or other minor alkaloids from C. roseus) exhibited binding affinities ranging from -3.42 to -9.32 kcal/mol, outperforming the reference standard binding affinity of -5.79 kcal/mol.