In vitro evaluation of antidiabetic and anti-inflammatory activities of terpenoid - rich ethyle acetate extracts from two endemic Artabotrys species

Members of the Annonaceae family are well known for their diverse therapeutic properties, as documented in numerous studies. The present study evaluated the in vitro antidiabetic and anti-inflammatory activities of Artabotrys zeylanicus and Artabotrys sahyadricus. Anti-inflammatory activity was assessed using inhibition of albumin denaturation and human red blood cell (HRBC) membrane stabilization assays. Antidiabetic potential was evaluated through α-amylase inhibition and α-glucosidase inhibition assays. The ethyl acetate stem bark extracts of both species exhibited notable anti-inflammatory activity, showing strong inhibition in both albumin denaturation and HRBC membrane stabilization assays. Among the two, A. sahyadricus demonstrated comparatively higher activity than A. zeylanicus in both assays. In addition, both plant species showed significant antidiabetic potential by inhibiting α-amylase and α-glucosidase enzymes, indicating their role in regulating and maintaining blood glucose levels.