Medicinal Plants - International Journal of Phytomedicines and Related Industries
SCOPUS
  • Year: 2014
  • Volume: 6
  • Issue: 2

Resveratrol oligomers from the tree bark of Shorea accuminatissima: Their properties and significance

1Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jalan Achmad Yani Tromol Pos 1 Pabelan, Kartasura, Surakarta 57102, Central Java, Indoneisa

2Faculty of Applied Sciences, Universiti Teknologi MARA, 40450, Shah Alam, Selangor Darul Ehsan, Malaysia

3Faculty of Applied Sciences, Universiti Teknologi MARA, 94300, Kota Samarahan, Sarawak, Malaysia

*Corresponding author: Haryoto e-mail: haryo62@gmail.com

Online published on 11 July, 2014.

Abstract

This study was aimed to isolate and structure elucidate the resveratrol oligomers from the acetone extract of the tree bark of S. accuminatissima. Five resveratrol oligomers, namely vaticanol-A, davidiol-A, α-viniferin, hopeaphenol and hemsleyanol-D have been isolated for the first time from this plant. The structures of these compounds were established based on the spectroscopic data evidence, including UV, IR, 1H NMR, and 13C NMR spectra, and compared to their reported data. Hopeaphenol showed cytotoxicity and strongly inhibited murine leukemia P-388 cells.

Keywords

Shorea accuminatissima, vaticanolA, hopeaphenol, murine leukemia P-388 cells, resveratrol oligomers