In vitro genotoxic effect evaluation of the Nigella sativa L. seed extract on human peripheral blood lymphocytes

H. Talbi; I. Talha; L. Amahdar; H. Sbayou; B. Charaf; J. Talbi; A. Hilali

Year: 2014
Volume: 6
Issue: 4

In vitro genotoxic effect evaluation of the Nigella sativa L. seed extract on human peripheral blood lymphocytes

Author:
H. Talbi^1,, I. Talha¹, L. Amahdar², H. Sbayou¹, B. Charaf¹, J. Talbi³, A. Hilali^1,2
Total Page Count: 5
DOI: 10.5958/0975-6892.2014.00019.7
Page Number: 293 to 297

¹Health and Food-Processing Industry Laboratory, Faculty of Sciences and Technics, Hassan 1st University. Casablanca Road Km 3,5 PB 539. Settat-Morocco

²High Institut of Health Sciences, Hassan 1st University. Casablanca Road Km 3,5 PB 539. Settat-Morocco

³National Laboratory of Scientific Police, Casablanca-Morocco

*Corresponding author: Hyat Talbi e-mail: hayattalbi@yahoo.fr

Abstract

This study aims to assess the genotoxic effects of the Nigella sativa L. seed extract on human peripheral blood lymphocytes. Human lymphocytes cells cultures were treated by eight different concentrations of the N. sativa seed extract. DNA damages (cytogenetic aberrations) and cells viability were assessed by the micronucleus (MN) test and the cell proliferation kinetics (CPK) respectively. Results showed that the sativa seed extract decreased significantly the CPK, cell viability and MN rate at increasing concentrations.

Keywords

Nigella sativa L, Genotoxicity, Cytogenetic, Micronucleus test, Cell Proliferation Kinetics

In vitro genotoxic effect evaluation of the Nigella sativa L. seed extract on human peripheral blood lymphocytes

Abstract

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