Prevalence and Phenotypic Characterization of Carbapenem-Resistant Escherichia Coli in Clinical Specimens from A Tertiary Care Hospital in North India

Carbapenem-resistant Escherichia coli is now a recognised global threat to human health due to the emergence and increasing prevalence of this resistance. To assess the original prevalence and phenotypic characterisation of carbapenem-resistant E. coli, the aim of this study was to detect carbapenemase production in Escherichia coli by the Disk diffusion (Kirby-Bauer method). The present study was carried out in the Department of Microbiology, Keral Verma Subharti College of Science, Meerut (U.P) and clinical samples were collected from the patients attending Subharti Medical College & Hospital, Meerut (U.P).A total of 206 E. coli isolates were examined regardingage, sex, departments and Carbapenem resistance among different clinical specimens suchas Urine, Blood, and Pus received in the microbiology laboratory. It was observed that out of 206 E. coli isolates, about 58 (28.15%) isolates were frommale patients, while 148 (71.84%) were from female patients. The majority (70.87%) of isolates were from urine samples. Out of 206E. coli isolates, a total of 64 (31.06%) were carbapenem-resistant. The prevalence of E. coli that is resistant to carbapenem is rapidly increasing and is now the most significant issue in the field of infectious illnesses. Therefore, it is now crucial to identify the shifting pattern of resistance as soon as possible to prevent the spread of resistant germs and modify treatment plans.