Field experiment was conducted during main seasons (March–July) of 1984 and 1985 on sandy loam acidic soil of Meghalaya to study the response of potato var. ‘Kufri Jyoti’ to N, P and K fertilization. Significant increase in the potato tuber yield was up to the application of 120 kg N, 180 kg P2O5 and 60 kg K2O/ha. However, the optimum economic dose of N, P2O5 and K2O was found to be 153.6, 164.4 and 123.8 kg/ha, respectively. The increase in the tuber yield was mainly associated with increase in the number of compound leaves and tubers/m2 as a result of application of nitrogen, phosphorus and potassium.