Disposition Kinetics and Residues of Cypermethrin in Tissues after Single Dermal Application to Black Bengal Goats

The disposition kinetics of cypermethrin were studied in goats after single dermal application of 100 ml of 0.25% (w/v) solution. The insecticide persisted in the blood for 96 hours. The mean Vd_(area) and apparent t_1/2 (B) were 6.87 ± 1.42 L kg⁻¹ and 19.25 ± 2.36 h, respectively, while the AUC and C1_B values were 89.76 ± 19.06 μg h ml⁻¹ and 0.26 ± 0.07 L kg⁻¹ h, respectively. Adrenal gland contained highest concentration of cypermethrin residues followed by the heart, omental fat, kidney, liver and cerebrum on 4^th d, while omental fat contained maximum residues on 8^th d post application. Cypermethrin caused hypoglycaemia and hypocholesterolaemia and increased serum acetylcholinesterase activities from 96 and 120 h post application.