*Present address: Division of Crop Production, Indian Grassland and Fodder Research Institute, Jhansi-284, U.P.
#Present address: AN-12C, Shalimar Bagh, Delhi-110 088
Three new series of 2-chloroethyl phosphonamidates were synthesized tested for herbicidal and phytotoxic activities on some test crops and weed in the pot. The biological efficacy values were compared with various physico-chemical parameters of the compounds by multiple regression analyses to develop quantitative structure-activity relationship (QSAR) models. The best fitted single-variable and two-variable models suggest that molar refractivity and steric parameters of the compounds are major determining factors in expression of bioactivity of the synthesized compounds.
Phosphonamidates, herbicides, phytotoxicity, wheat, mustard, wild oot, QSAR
