Synthesis of Some Benzopyridazines as Antifungal Agents

Some new l-(substituted thioanilido)-8-keto-3-substituted benzopyridazines (III) were prepared by reacting 4-aryl-3- thisemicarbazides with either 2- (substituted benzoyl) benzoic acid or 2-carboxy benzaldehyde/2-carboxyl (substituted benzophenone) (I). Thiosemicarbazones (II) thus formed on cyclodehydration gave the titled compounds. These benzopyridazines were screened for their antifungal’ activities. Based on screening data, some structure activity relationship has been established.