Synthesis and Fungitoxicity of Propenylamino and Pyrazolinylcarboxamido Derivatives of 1,2-Diphenyl ethane

Five 1,2-bis (4-propenylaminophenyl) ethane derivatives and ten 1,2-bis [4-(pyazolinylcarboxamido) phenyl] ethane derivatives were synthesised and characterised by elemental analysis, IR, ¹HNMR and mass spectral studies. These compounds were evaluated for their fungicidal activity against Fusarium oxysporum and Penicillium citrinum. All the compounds exhibited fungicidal activity against the test fungi. 1, 2-bis [4-(1¹-acetyl-5¹-chlorophenyl-3¹-methyl-2¹-pyazolin-4¹-ylcarboxamido) phenyl] ethane was found to be the most active compound against both fungal species. It exhibited activity comparable to Dithane M-45, a commercial fungicide. The structure-activity relationship of these compounds revealed that 1,2-bis (4-pyrazolinylcarboxamidophenyl) ethane derivatives having haloaryl group were superior to others.