Synthesis and Insecticidal Activity of 2-[4-(4,5-di hydro-5-(substituted phenyl)-1H-Pyrazol-3-yl)phenoxy] Acetic Acid Hydrazides and Related Compounds

Condensation of 4-hydroxyacetophenone (1) with substituted aldehydes (2–8) gave various 1-(4-hydroxy phenyl)-3-(substituted phenyl) prop-2-en-1-ones (9–15). Alkylation of chalcones(9–13) with ethyl chloroacetate in presence of anhydrous potassium carbonate gave the corresponding ethyl 2-[4-(substituted cinnamoyl) phenoxy] acetates (16–20), respectively. Hydrolysis of various esters (16–20) gave 4-(substituted cinnamoyl) phenoxy acetic acids (21–25). Compounds 16–20 were also refluxed with hydrazine hydrate to afford 2-[4-(4,5-dihydro-5-(substituted phenyl)-I H-pyrazol-3-yl)phenoxy] acetic acid hydrazide (26–30). These compounds were characterized and evaluated for their insecticidal activity against Helicoverpa armigera and some ef them exhibited dignificant insecticidal activity.