Synthesis, In Vitro Antifungal Evaluation and Structure Activity Relation of the Schiff Bases of Some Primary Amines against Ustilago Tritici.

Two novel series of Schiff bases viz. N-benzylidene-2-phenylethanamines and 2-phenyl-N-(1-phenylethylidene) ethanamines were synthesized and evaluated for their fungitoxicity, along with two related series viz. Nbenzylidene-1-phenylmethanamines and N-benzylideneanilines, against Ustilago tritici. The SAR (Structural Activity Relation) analysis was done to observe the effect of dimension of spacer between the two phenyl rings of Schiff bases on the fungitoxicity. Increase in length of spacer had shown positive influence on fungitoxicity. Further, computational analysis of the series revealed the topological dependence of fungitoxicity on some of these factors.