Pesticide Research Journal
SCOPUSWeb of Science
  • Year: 2011
  • Volume: 23
  • Issue: 2

Synthesis and Antifungal Activity of Dispiro-1,2,4-Trioxolane Derivatives

  • Author:
  • Pooja Tanwar1,, GC Yadav, UK Jaitley2, P Dureja3
  • Total Page Count: 5
  • Page Number: 213 to 217

1Drug Regulatory Affairs, Ranbaxy Research Laboratories, Gurgaon 222 001, Haryana, India

2Department of Chemistry, RSS (PG) College, Ghaziabad, Uttar Pradesh, India

3Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi 110 012, India

*Corresponding author E-mail: poojatanwar@ranbaxy.com

Abstract

Ten substituted dispiro-1,2,4-trioxolane derivatives were synthesised and screened for antifungal activity in vitro against Rhizoctonia bataticola (Taub) Butler and Sclerotium rolfsii (Sacc.). Dispiro[cyclohexane-1,3’[1,2,4]trioxolane-5’,2"-tricyclo [3.3.1.13,7] decan]-4-yl)-N-(3-fluorobenzyl) acetamide (9b) showed maximum activity against S. rolfsii with ED50 46.90 μg/ml and N-cyclooctyl-2-(dispiro[cyclohexane-1,3’-[1,2,4] trioxolane-5’,2"-tricyclo [3.3.1.13,7] decan]-4-yl) acetamide (9g) showed maximum activity against R. bataticola with ED50 58.23 μg/mL. The antifungal activity of these compounds was less as compared to standard fungicide hexaconazole (ED50 = 13.43 and 18.30 μg/ml against S. rolfsii and R. bataticola respectively).

Keywords

Dispiro-1, 2, 4-Trioxolane derivatives, antifungal activity, Rhizoctonia bataticola, Sclerotium rolfsii