Synthesis and Antifungal Activity of Enaminone Derivatives against Sclerotium rolfsii and Fusarium oxysporum

A series of 20 enaminone derivatives were synthesised by condensation of substituted 2-hydroxy acetophenone derivatives with N, N-dimethylformamide dimethylacetal. The synthesized compounds were characterized using various spectroscopic techniques including Infrared spectroscopy, ¹H Nuclear Magnetic Resonance, ¹³C Nuclear Magnetic Resonance spectroscopy and High Resolution Mass Spectroscopy. All the synthesised compounds were evaluated for antifungal activity against Sclerotium rolfsii and Fusarium oxysporum. In vitro fungicidal bioassay revealed that compound 3p, 3-dimethylamino 1-(3,5-dichloro-2-hydroxyphenyl) propanone was found most active against S. rolfsii (ED₅₀ = 28.12 ppm). In case of F. oxysporum, compound 3t, 3-dimethylamino-1-(5-chloro-2-hydroxy-4-methyl-phenyl) propanone showed highest activity (ED₅₀ = 38.19 ppm). These results showed that compound 3p can be considered as potential antifungal agent against S. rolfsii.