Analytical Techniqes for Clopidogrel Bisulphate: Review

P2Y12 is a purinergic G protein-coupled (GPCR) receptor that binds to adenosine diphosphate (ADP). Thromboembolisms and other clotting diseases can be treated by targeting the P2Y12 receptor, which is involved in platelet aggregation. The morbidity and mortality outcomes, such as cardiovascular death, recurrent myocardial infarction (MI), and stroke at 30 days following percutaneous coronary intervention (PCI), have improved with the use of clopidogrel (CLO). One such medication that selectively and permanently blocks the P2Y12 subtype of the ADP receptor is CLO. This paper provides a thorough explanation of different analytical techniques that have been published for the determination of CLO and its combined forms in biological matrices and pharmaceuticals. The review focuses on both fundamental and sophisticated methods used to estimate CLO. The review shows that the technique of HPLC with UV detection was commonly used, even if various analytical methods were used for the CLO assay.