Research Journal of Pharmaceutical Dosage Forms and Technology
  • Year: 2009
  • Volume: 1
  • Issue: 2

Anti-Inflammatory Activity of Ethanolic and Acetone Extracts of Bauhnia variegate

  • Author:
  • D Sheshadri Shekar, C Velmurugan, G Ramakrishnan, B Vivek
  • Total Page Count: 3
  • Page Number: 97 to 99

Department of Pharmacology, Sri K.V. College of Pharmacy, M.G.Road, Chickballapur-562101

*Corresponding Author: Dr. D. Sheshadri Shekar, Principal, Dept. of Pharmacology, Sri. K. V. College of Pharmacy, M. G. Road Chickballapur-562101, Karnataka. Email: sheshadrishekar@gmail.com

Online published on 19 March, 2013.

Abstract

The ethanolic and acetone extracts of Bauhnia variegate bark was examined for anti-inflammatory in experimental animals. In this study both acute and sub-acute inflammation models were used to evaluate the antiinflammatory activity of the Bauhnia variegate. In acute model carrageenan was used to induce inflammation in rat hind paw and in sub-acute inflammation, cotton pellet induced granuloma was performed. The bark of ethanolic and acetone extracts of bauhnia variegate at the doses of 400 mg/kg shows significant (p<0.001) inhibition of inflammation against both acute and sub-acute anti-inflammatory model. The percentage inhibition of ethanolic and acetone extract of Bauhnia variegate both acute and subacute anti-inflammatory model was 35.29%, 43.14% and 33.53%, 42.20% respectively. According to our results both the extracts of Bauhnia variegate in doses of 400 mg/kg reveals anti-inflammatory activity and supports tribal claim.

Keywords

Anti-inflammatory, Carrageenan, Cotton pellet granuloma, Bauhnia variegate.