Research Journal of Pharmaceutical Dosage Forms and Technology

The aim of the present study is to investigate the physicochemical equivalence of five brands of tablets containing paracetamol purchased from different retail pharmacy outlets in Hyderabad, Andhrapradesh, India. The tablets were evaluated for uniformity of weight, friability, hardness, thickness, disintegration, dissolution and assay. All the five brands of the tablets passed the Indian Pharmacopoeia (IP) standards for all in vitro evaluation tests. There was no significant difference in the amount of paracetamol released from the different brands (P>0.05). These results indicate that the tablets of paracetamol purchased from retail outlets in Hyderabad are manufactured and marketed from WHO GMP certified Indian companies. Further work is recommended on bioequivalence of these tablets.