Formulation and In Vitro-In Vivo Evaluation of Alfuzosin Hydrochloride Floating Matrix Tablets

The aim of the study was to develop and physicochemically characterize single unit controlled delivery system of alfuzosin hydrochloride and was formulated as floating matrix tablet by direct compression method using gas generating agent (sodium bicarbonate) and various viscosity grades of hydrophilic polymers (HPMC K15M, K4M; HPC and Carbopol 934P). Formulation was optimized on the basis of buoyancy and in vitro drug release profile. Also tablets were tested for various tests like hardness, thickness, weight variation, friability, swelling index and erosion index. The tablets swelled and eroded upon contact with release medium (0.1 N HCl) at 37°C. The release rate could efficiently be modified by varying the matrix forming polymer, the use of polymer blends and the addition of water soluble or water insoluble fillers (such as dicalcium phosphate, lactose or mannitol).The physical blends were analyzed for FT-IR,DSC study and showed no incompatibility. Also SEM study was used to visualize the effect of dissolution medium on matrix tablet surface. Fitting the in-vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release.