1Dept. of Pharmaceutical Analysis, KNV Pharmacy College, Metoda-360021, Rajkot, India
2Dept. of Quality Assurance, Lachoo Memorial College of Science and Technology, Shastrinagar-342003, Jodhpur, India
3Vidyabharati Trust College of Pharmacy, Umarakh, Surat, India
*Corresponding Author: Ashok P Suthar, K.N.V. Pharmacy College, Village: Metoda, Rajkot, India – 360021, Email: kumar4a@gmail.com
Online published on 19 March, 2013.
New simple, economic, sensitive, accurate UV Spectrophotometric method has been developed for determination of Risperidone in tablet dosage form. Method of estimation for Risperidone based on two wavelengths viz. 238 nm and 276 nm, by solvent mixture of 0.1N HCl: Methanol in the proportion of 30:70. Risperidone shows linearity and obeys Beer's law in the concentration range of 3 to 27μg ml−1 at both wavelengths. The results of analysis are validated by statistical evaluation and recovery studies, and method can be extended to the analysis of Risperidone in tablet formulations. A kinetic investigation of the peroxide hydrolysis of Risperidone was carried out in 1% and 3% Hydrogen peroxide solution. The rate constant for degradation were estimated as per pseudo-first order kinetic.
Risperidone, UV Spectrophotometric method, Amax, Degradation kinetic
