1Department of Pharmaceutics, GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P.
2Girijanada Chowdhury Institute of Pharmaceutical Science, Azara Hathakhowapara, NH-37, Guwahati, 781017, Assam
*Corresponding Author: Choudhury A, GRY Institute of Pharmacy, Vidya Vihar, Borawan, M.P. E-mail: ananta_hpi@yahoo.co.in, PH: 09893515345
Online published on 19 March, 2013.
The purpose of the study was to develop a floating control drug delivery system of ranitidine hydrochloride and investigate the effect of formulation variables on drug release profile and floating property. Ranitidine hydrochloride (RHCl) was used as a model drug because of its short biological half life and site of release at stomach. Tablets were formulated using different concentration hydroxypropyl methyl cellulose K4M, carbopol 934.where Sodium bicarbonate and Citric acid used as a gas generating agent. The floating behavior and in-vitro dissolution studies are carried out in a USP type II apparatus in 0.1 (N) HCL. It was observed that all the prepared formulation shows good floating capabilities up to 15 to 18 hours and slow steady release profile up to 12 hours. The dissolution profiles were subjected various kinetic release equations and found that drug release from different polymeric matrix follows diffusion controlled process. It has been also observed that combination of HPMC K4M and carbopol 934 shows better results as compared to their single use.
Floating controlled delivery system, Ranitidine Hydrochloride, Hydroxypropyl methylcellulose K4 M, Carbopol-934
