Department of Pharmaceutics, MVPS's College of Pharmacy, Shivaji Nagar, Gangapur Road, Nashik-422002, Maharashtra, India
*Corresponding Author: Kothawade Paresh Ichharam MVP College of Pharmacy, Shivaji Nagar, Gangapur Road, Nashik, Maharashtra, India. 422005 Phone No.: 09960559394; (0253)2573294 Email: pareshk5569@yahoo.co.in, pareshk5569@gmail.com
Online published on 19 March, 2013.
Human being shows chronological behaviour with time clock. Chronotherapy is designed accordingly to the chronological behaviour of body. It delivers drug at specific time, at specific site and in specific amount to overcome the problem of conventional modified drug delivery system. It is advantageous to treat disease showing chronological behaviour, such as cardiovascular disease, asthma, rheumatoid arthritis and ulcers. These systems are also beneficial for the drugs having chronopharmacological behaviour where night time dosing is required and for the drugs having high first-pass effect and having specific site of absorption in GIT. Various methodologies are employed for developing chronotherapeutic system like time controlled, self regulating and externally modulated system. Chronotherapy based drug delivery system like OROS®, CODAS®, DIFFUSCAP®, CEFORAM®, PULSINCAP® are available in market. Due to such beneficial characteristics chronotherapy should be promising in the future.
Chronotherapy, PULSINCAP®, OROS®, single/multiple unit
