1Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune, 411 041, Maharashtra, India
2Govt. College of Pharmacy, Karad, 415124, Maharashtra, India
*Corresponding Author: Amelia M. Avachat Sinhgad College of Pharmacy 44/1, Vadgaon (Bk.), Pune -411 041 Maharashtra, India Phone No. +91 98224 56636, Email: prof_avachat@yahoo.com, Fax No.: 020 24354720
Online published on 19 March, 2013.
Rifampicin (RMP) and Isoniazid (INH) are highly unstable in liquid dosage form and there is no liquid product available. A novel concept of formulating a suspension of RMP and INH for pediatric and geriatric application has been tried. The reconstitutable dry syrup which can be reconstituted by using a special vehicle has shown very good stability at 28°C and at 25°C for more than 1 month and 14 days respectively using a stability indicating HPLC method. The in vitro dissolution studies have revealed no adverse impact of special vehicle on dissolution. Thus this combination product could prove to be a major boost for the market need for pediatric patients.
Rifampicin, Isoniazid, suspension, stability
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