Formulation and Evaluation of Sustained Release Matrix Tablets of Propranolol Hydrochloride Using Hydroxyethyl Guar as Rate Sustaining Polymer

Hydroxyethyl guar (HEG), which is a guar gum derivative, was investigated as a sustaining material to formulate sustained release tablets of the model drug, Propranolol hydrochloride. Tablets, based on HEG polymer were made keeping the hardness constant. In vitro release rate study was carried out for all the formulations and curve-fitting analysis was done on the selected formulation.

A swelling index study was also carried out. The selected tablets were kept for accelerated stability study. The study indicated that the guar derivative, HEG, could be utilized for formulation of sustained release tablets of Propranolol hydrochloride. All the selected formulations were found to be physically and chemically stable at different storage conditions at the end of the eight week.