Research Journal of Pharmaceutical Dosage Forms and Technology

In the present work, microspheres of Candesartan using Sodium alginate along with Carbopol 934, Guar gum and HPMC K4M as copolymers were formulated to deliver Candesartan via oral route. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Candesartan microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymers used. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 512–834μm and are suitable for microspheres for oral administration. Increase in the polymer concentration lead to increase in % Drug entrapment efficiency, Particle size, % swelling. The in-vitro study demonstrated that microspheres of Candesartan using sodium alginate along with Carbopol 934, Guargum and HPMC K4M as copolymer. The invitro drug release decreased with increase in the polymer and copolymer concentration. Based on the results of evaluation tests formulation coded F9 was concluded as best formulation. Drug release profile of pure drug, optimized formulation and the marketed tablet was compared and the drug release of the marketed formulation was found to be 73.80% due to its hepatic first pass metabolism. And the drug release of the optimized formulation was found to be 98.55%. Stability studies are conducted for optimized formulation at 5⁰, 25⁰, 60% RH, 30°C/65% RH for a period of three months. Stability studies shown no changes in the product after 3 months, it is considered as a stable product.