The purpose of study was to developed and optimized nanoemulsion containing ketoconazole for antifungal delivery. ketoconazole has absolute bioavailability of due to high first pass metabolism. Ketoconazole nanoemulsion and were prepared by titration method. Tternary phase diagram give the nanoemulsion region and the concentration of oil Smix and water were selected from ternary phase diagram. Based on solubility study seaseam oil, twine 80, ethanol were selected as oil, surfactant, co-surfactant respectively. Nanoemulsion were prepared using water titration method.1.1% v/v ratio (Tween 80: ethanol) was selected for formulation development. The nanoemulsion were optimized optical transparency, viscosity measurement, phase separation determination of pH, measurement of globule size, zeta potential, drug content, invitro diffusion study, stability study.
Emulsion, Nanoemusion, Antifungal, Ketoconazole
