Comparative Study of Etoricoxib Loaded Solid Dispersion and Beta-cyclodextrin Complexes for improvement of Dissolution Profile

Solid dispersions of Etoricoxib were prepared using polyethyleneglycols in different proportions by fusion and solvent evaporation method. Physical mixtures were also prepared in same proportions by simple kneading. Batch F6 containing drug: PEG4000 1:4, having greater saturation solubility, was selected and formulated in tablet (batch TF6) and evaluated for in-vitro drug dissolution and sixmonth stability. The results were compared with that of tablet containing physical mixture of drug: PEG4000 in the same ratio (batch TP6) and conventional tablet containing plain Etoricoxib (batch CT). Tablet TF6 has shown significant improvement of dissolution profile of Etoricoxib when compared with that of tablet TP6 and CT. Present study conclusively suggested that PEG4000 enhanced water solubility of Etoricoxib by amorphisation, which was confirmed by XRPD, FTIR, SEM and DSC. The study also demonstrated that solid dispersions can be successfully stabilized by non ionic surfactants.