Formulation and evaluation of aceclofenac-loaded nanoparticles by solvent evaporation method

Nanoparticles have applications in the formulation of poorly water soluble drugs to improve their bioavailability. Preparation and evaluation aceclofenac-loaded nanoparticles by solvent evaporation method to enhance solubility and bioavailability were the primary aim of the present investigation. Nanoparticles of aceclofenac, a BCS class II drug were prepared by solvent evaporation technique and characterized using Fourier transform infrared spectroscopy, particle size and zeta potential, scanning electron microscopy and drug release studies in vitro. Data from the Fourier-transform infrared spectroscopy showed no interaction between drug and the polymers. Scanning electron microscopy images indicated that nanoparticles were spherical in shape. Water solubility of drug-loaded nanoparticles was increased as compared to the pure drug and showed improved dissolution profile, which indicated that nanoprecipitation, was simple and precise. This laboratory scale method as well as this approach could be employed for solubility and bioavailability improvement of aceclofenac.