Formulation and in-vitro evaluation of sustained release matrix tablets of valsartan using beta-cyclodextrin

In the presented work formulation and in-vitro evaluation was carried out for tablets containing Valsartan as Sustained Release using HPMC and Beta-Cyclodextrin polymers by wet granulation method. The tablets were subjected to in-vitro drug release study in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The drug released at various time intervals were determined by validated UPLC-PDA method. The prepared tablets showed better sustained release effect when compared with marketed tablets. The formulated tablets provided sustained release of Valsartan over a period of 24 h.