1Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh, 176031, India
2Department of Pharmaceutical Chemistry and Analysis, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh, 176031, India
3Research Scholar, Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, Sector-125, Noida, 201303, India
*Corresponding Author E-mail: shammyjindal@gmail.com
Online published on 4 May, 2021.
Psoriasis is a most common long lasting chronic autoimmune inflammatory skin disease. Psoriasis is affecting approximately 2% - 3% of world population. The possibility to develop psoriasis by causing emotional stress, infections, intestinal abnormal and specific medications. The present paper aimed to investigate the effect of permeation enhancer on permeation of hydrogels prepared with Berberine hydrochloride. The Berberine hydrochloride is herbal phytoconstituents which obtained from the plant of Tinospora cordifolia. The hydrogels was prepared by using Carbopol 934. The prepared hydrogel was evaluated for physical appearance, drug content, pH, viscosity, spreadability, homogeneity, grittiness and in-vitro release. The effect of permeation enhancers was examined to enhance the drug release profile up to 8hours, when compared with or without permeation enhancers. The mechanism of drug release was found to be non-Fickian. From the results it was concluded that permeation of Berberine hydrochloride hydrogel was enhance release by using transcutol P in two concentration (0.1% and 0.2%).
Psoriasis, Berberine hydrochloride, Hydrogel, Transcutol P and Drug release
