Formulation and evaluation of transdermal patches of decongestant drug

Pseudoephedrine HCl (PEH) is a sympathomimetic drug used as a nasal decongestant. In this study an attempt has been made to formulate transdermal films of PEH using HPMC and PVP as polymers, DMSO as plasticizer and DBP as permeation enhancer by solvent casting technique. The prepared films were evaluated for various physicochemical parameters viz., weight variation, drug content, surface pH, folding endurance, tensile strength WVTR and stability studies of optimized formulation. The in vitro drug release was determined by using modified Franz diffusion cell by using phosphate buffer (pH 7.4) as diffusion medium. Among the two polymers used the HPMC has given the good results with formulation F6 emerged out as a best formulation among all six prepared by using with flux of 28.23 ±1.202 mentioned polymer alone and in combination. The obtained results concluded that the PEH transdermal films are promising delivery system in the treatment of nasal congestant.