Microballoons: An advanced avenue for gastro retentive drug delivery system

The motivation of writing this review on micro balloons is a Gastro retentive drug delivery system are micro balloons (hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug delivery system is novel drug delivery on the foundation of non-effervescent system that containing empty particles of spherical shape without core ideally having a size less than 200 micrometers which is designed to be retained in the stomach for a prolonged period of time and release their active ingredients and thereby enable sustained and prolonged input of the drug in the upper part of the gastrointestinal (GI) tract. They are gastro retentive drug-delivery systems, which provide controlled release properties for a drug. Recently gastro retentive drug delivery system (GRDDS) are gaining wide acceptance for drugs with narrow absorption windows, decreased stability at high alkaline pH, and increased solubility at low pH. The design of this article is to compose the various gastro retentive arrive. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling retention i.e. high density, floating, bio-or that adheres to a mucous membrane (adjective), extensile, attractor etc. In addition of central element controlling gastro retention, superiority and finally future potential are discussed.