Development and Evaluation of Bilayer Tablets of Bimodal release of Bisoprolol Fumarate

Bisoprolol is a type of antihypertensive drug (β-blocker). It is a poorly water-soluble and highly permeable drug that belongs to class II biopharmaceutical classification. This investigation represents the formulation development of bisoprolol to immediate and sustained the drug release. In immediate release different types of polymers like Sodium Starch Glycolate, Crospovidone and Lactose were used in this study. In sustained release different types of polymers like HPMC, Guar Gum and Magnesium Stearate were used in this study. Eight different formulations were developed by using different excipients at various ratios. The powder blend was evaluated for bulk density, tapped density, flow property whereas tablets were evaluated for thickness, hardness, weight variation, compressibility index, uniformity of content, disintegration time, and drug release profile. The present study concluded that bilayer tablets of Bisoprolol Fumarate as an alternative to the conventional dosage form.