Formulation development and evaluation of pantoprazole floating tablet by using 2 level factorial design

Pantoprazole, a proton pump inhibitor, is utilized to treat various gastric ailments such as benign gastric ulcers, acute ulcers of the duodenum, and GERD (gastric reflux disease). The purpose of this study was to use the direct compression approach to generate and optimize pantoprazole floating tablets. Key excipients like HPMC K4M, cyclodextrin, sodium bicarbonate, citric acid, and microcrystalline cellulose were employed. Using a Rotary tablet punch machine, the components were sieved, combined, and compressed into tablets. Lubricants like talc and magnesium stearate were subsequently added. Preformulation examinations assessed drug/polymer interactions by FTIR analysis and confirmed suitable excipients. A number of parameters were assessed for the tablets, such as buoyancy, floating lag time, hardness, thickness, friability, weight fluctuation, percent assay, and in vitro dissolution. The outcomes were within reasonable bounds and performed well in comparing with commercialized formulations. Among the formulation code F1, F2, F4, F5, F7, and F8 demonstrated good floatation properties, while F1 and F4 exhibited moderate floatation. The findings suggest that the floating pantoprazole tablet formulation enhances gastric residence time and bioavailability, thereby increasing therapeutic efficacy.