Formulation development and evaluation of sustained release floating beads of aspirin

The objective of this present investigation was to formulate, develop and evaluate gastro-retentive floating sustained release alginate beads of Aspirin it was prepared by the simple ionotropic gelation method and it provides better product and result. The floating beads were prepared by dispersing Aspirin together with aluminum dichloride (2 % w/v) (as gas forming agent) into a solution of sodium alginate and HPMC K4M, HPMC K15M, HPMC K100M. The resulting solution was then extruded through a 22-gauge syringe needle into 100 ml cross-linking solution containing calcium chloride (2 % w/v) plus acetic acid (10% v/v). Prepared beads were evaluated for their micromeritic characteristics, particle size, encapsulation efficiency, buoyancy test. The drug entrapment efficiency was increased with the increment of polymer ratio. All of the formulations (ASP1 to ASP5) floated immediately or with a very short lag time and remained floating up to 11 hours. Gastroprotective multiarticulate drug delivery system of drugs like aspirin for the effective management of muscles aches, inflammation and headaches. Rough and porous surface was observed in microscopic. The beads demonstrated favorable in-vitro floating ability. Prepared formulations showed better sustained release behavior. It was concluded that beads of Alginate could be serve as an effective carrier for drugs like aspirin for the sustained release drug delivery.