Formulation and Characterization of Polymeric Microspheres Loaded with Sesamol for Improving Bioavailability

In order to increase the drug's bioavailability, the work’s goal was to create Sesamol-loaded microspheres using chitosan and sodium alginate as a polymeric matrix. Using different amounts of chitosan and a set concentration of sodium alginate, the microspheres were created using the ionic gelation process. The prepared microspheres were characterized by entrapment efficiency, particle size, in vitro drug release, scanning electron microscopy (SEM), and FT-IR. The in vitro drug released ranged from 94.36 to 98 % from the microsphere formulations at the end of 12 hours of the study. The formulations’ average particle sizes varied from 29.88 ± 18.14 μm to 35.36 ± 16.37 μm. The microsphere formulations’ drug contents varied from 67.45 to 89.71%. The developed microspheres indicated prolong drug release 12 hrs. The optimized batch F4. According to results of research Sesamol loaded microspheres sodium alginate and chitosan as polymeric matrix to improve bioavailability of the drug.