Development of Combinatorial Aqueous Herbal Extract Loaded Orodispersible Tablets for the Prevention and Treatment of COVID-19

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) is considered as major life-threatening disease and dangerous to human population worldwide. The symptoms are related with upper and lower respiratory tracts like cough, fever and headache are visualized during viral infection and at last fatal if condition remains chronic more than 10 days. AYUSH (Ayurveda, Yoga, Unani, Siddha and Homeopathy) and WHO (World Health Organization) recommended Kabasura Chooranam (KC), a polyherbal formulation which contains 15 potent medicinal property containing phyto powders, plays a vital role in targeting SARS-CoV-2 and their pathway. The KC is consumed by infusing the powder in water and making it as decoction. Administration of KC in the form of oral liquids is a convenient method, but in some instances, during the time of infection patient might be in isolation at that time preparation of liquid from powders is quite difficult also it require heat for doing the preparation. Hence it requires people assistance and there may be a risk to spread the virus to the people surroundings. Degradation of KC aqueous extract on prolonged time storage may produce instability. It has higher chance of dose variability since the delivery of the dose depends upon the patient measuring the proper volume. The taste is usually unpleasant is always more prominent when in solution than in a solid form. For increasing stability time, producing fast actions, consuming required dose and masking bitter taste, an attempt of oral dispersible tablet has been developed. The main objective of this study is to overcome the dyspepsia in pediatric, geriatric and sickly affected patients by formulating a polyherbal oral dispersible tablet for the management, treatment and to boost immune response against COVID-19 virus.