Evaluation of Formulated Luliconazole Lipid Nano Particle Gel Targeting Topical Fungal Infections

A topical imidazole antifungal medication with broad-spectrum action is luliconazole. Nevertheless, it faces difficulties such as poor penetration, skin retention, and aqueous solubility, which lower its cutaneous bioavailability and impair its effectiveness in drug delivery. Formulating and characterizing luliconazole-loaded nanostructured lipid carriers for topical fungal infections was the goal of the current investigation. A modified solvent diffusion approach was used to produce the LCZ-SLNs following preformulation investigations. Key parameters such as poly-dispersity index (PDI), zeta potential, encapsulation efficiency (EE%), and Fourier transform infrared (FTIR) analysis were assessed during the characterization process. In vitro drug release kinetics were also examined. The results indicated that LCZ-SLNs exhibited favorable zeta potential, homogeneous dispersion, and nanoscale dimensions. The encapsulation efficiency of LCZ in SLNs was nearly 90%. FTIR analysis revealed no chemical interactions between LCZ and excipients. In vitro drug release tests showed that LCZ-SLNs substantially enhanced the drug's dissolution rate. Stability testing demonstrated consistent colloidal nanometer sizes in the LCZ-SLNs samples. The study suggests that the LCZ-SLNs formulation could be a promising option for topical treatment of superficial fungal infections.