Formulation and Evaluation Flurbiprofen Solid Dispersion for Solubility and Dissolution Enhancement

The main purpose of this research is to enhance the solubility and how fast the drug Flurbiprofen dissolves in water. This drug is accustomed to use swelling and pain and is not extremely solvable in water. To assist with this, the drug was created into a solid dispersion utilize distinct kind of hydrophilic polymers. The investigation seems at how well the drug dissolved in numerous polymers like PVP-K30, HPMC, and PEG 6000. Five distinctive solid dispersion formulations were made using the solvent evaporation method along with varied polymers. Each formulation was tested for particle size, how much drug was in the formulation, and how well it dissolved in water. Based on these tests, the best formulation was SD5. The formulation SD5, which used Flurbiprofen, and sodium lauryl sulfate in a ratio of 1:5:2, showed the fastest drug release, with 99.86% released within 15 minutes. Also, the solubility of the drug in SD5 was 44 times better than the solubility of the pure drug. To coincide if the drug and the other ingredients worked well together, FTIR and XRD tests were done. The results showed that the drug and the polymers were compatible, and the best formulation had an amorphous structure, which helped the drug dissolve better than the pure drug. This shows that using this method can help increase the body's ability to absorb the drug, which is important for drugs that don't dissolve well in water.