Fabrication and Characterization of Novel Repaglinide Incorporated Buccal Film for the Management of Type-2 Diabetes

A study was conducted on repaglinide, an antihyperglycemic agent, used in the management of non-insulindependent diabetes mellitus, to design and characterize bioadhesive buccal films to overcome hepatic first-pass metabolism. The films are prepared using various ratios of bioadhesive polymers like HPMC, chitosan, and carbopol. For elucidating the physicochemical compatibility between the drug and the used polymers, FT-IR spectroscopy was employed. The prepared films were evaluated for in vitro drug release, bioadhesion strength, swelling index, moisture absorption, and surface pH.