Preparation and Evaluation of Intra-Vaginal Gel: A Review

Purpose of this article is to introduce about the vaginal drug delivery, preparation of intra – vaginal gel and methods used for the evaluation of most effective intra – vaginal gel. Perhaps vagina is less explored, but efficient route for administration of drugs due to the presence of dense blood vessels network. To date, most vaginal drug delivery systems are traditionally used to deliver contraceptives and drugs to treat vaginal infections. However, vaginal drug delivery is not limited to these drugs as the vagina has promise as a site to topically deliver drugs which will be absorbed systemically because of the dense network of blood vessels in the vaginal wall. This is an advantage over other routes of transdermal and trans-mucosal drug delivery. In addition, vaginal drug delivery has an advantage over oral delivery because it avoids the hepato-gastrointestinal first-pass metabolism of drugs. This review article contains classification of gel, mechanism of absorption, and method of preparation and evaluation of intra-vaginal gel is also well explained in this review article.