Effect of Solid Dispersion Technique on Improving the Solubility of Roxithromycin

Roxithromycin, an antibacterial agent is widely used in the treatment of various infections. One of the major problem with this drug is its low solubility in biological fluids. Therefore, solid dispersions of roxithromycin were prepared using mannitol as carrier by different techniques like physical mixing, melting method, melt solvent method, kneading technique and common solvent method to improve the aqueous solubility. Solid dispersions were prepared in 1:1, 1:2, 1:4 and 1:9 ratios of drug to carrier. Prepared solid dispersions were evaluated for solubility, content uniformity, dissolution rate and efficiency. More solubility and faster dissolution was exhibited by solid dispersions containing 1:4 ratio of drug and carrier prepared by melting method. FT-IR studies revealed the absence of significant drug-carrier interactions.