East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049
*Corresponding Author: Preethi Sudheer, Department of Pharmaceutics, East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049, India. Email: preethiksudheer@rediffmail.com
Online published on 19 March, 2013.
Lipid microspheres of ketoprofen was prepared by emulsification method using waxes such as bees wax, carnauba wax and cetosteryl alcohol. These microspheres were evaluated for in-vitro dissolution studies, thin layer chromatography, scanning electron microscopy and particle size analysis. Lipid microspheres were studied for diffusion characteristics using cellophane membrane and permeation characteristics through excised rat abdominal skin. Lipid microspheres were found to increase the rate of permeation of poorly absorbable ketoprofen, so they may be used as a potential carrier in increasing the rate of absorption in case of topical delivery of drugs.
Lipid microspheres, ketoprofen, emulsification, diffusion
